Table 4. Logistic regression analyses of factors associated with EIM development in patients with UC.

Factors	Univariate analysis			Multivariate analysis
	OR	95% CI	P	OR	95% CI	P
Sex (male vs. female)	0.56	0.10–2.74	0.479
Age at diagnosis, yr	1.15	0.91–1.52	0.286
Age at follow-up, yr	1.00	0.78–1.33	0.988
Disease extent of E4 (yes vs. no)	1.76	0.65–9.89	0.183
Disease severity of S1 (yes vs. no)	10.50	1.89–86.04	0.012	16.57	2.18–287.39	0.017
PUCAI at diagnosis	1.04	0.99–1.11	0.109
CRP at diagnosis, mg/dL	1.08	0.79–1.41	0.596
ESR at diagnosis, mm/hr	1.05	1.00–1.10	0.056	1.06	1.00–1.14	0.054
FC at diagnosis, mg/kg	1.00	1.00–1.00	0.903

EIM = extraintestinal manifestation, UC = ulcerative colitis, E4 = pancolitis (proximal to hepatic flexure), S1 = ever severe (PUCAI ≥ 65), PUCAI = Pediatric Ulcerative Colitis Activity Index, CRP = C-reactive protein, ESR = erythrocyte sedimentation rate, FC = fecal calprotectin, OR = odds ratio, CI = confidence interval.