Table 2.

SNE effects on cell proliferation and cell cycle related genes expression profiles.

Biological Function Categories	Diseases of Functions Annotation	p-Value	Molecules (up (↑) or down (↓) Fold)
Cell Cycle	Exit from mitosis of breast cancer cell lines	2.80E-04	CCNE1 (1.49↑), CDKN1A (1.58↑)
DNA Replication, Recombination, and Repair	DNA damage	7.32E-03	ESR1 (0.70↓), RRM2 (1.55↑)
Gene Expression	Binding of estrogen response element	7.32E-03	CXCL12 (0.60↓), ESR1 (0.70↓)
Cell Cycle	senescence of breast cancer cell lines	1.65E-02	CDKN1A (1.58↑), ESR1 (0.70↓)

Altered gene expression profiles in MCF7 cells by adding of 1 mg/ml SNE were performed using Agilent Microarray and Ingenuity Pathway Analysis (IPA). CCNE1; cyclin E1, CDKN1A; cyclin dependent kinase inhibitor 1A, ESR1; estrogen receptor 1, RRM2; ribonucleotide reductase regulatory subunit M2, CXCL12; C-X-C motif chemokine ligand 12.