Table 2:

Summary of socio-demographic and vascular risk data for SVD and control cohorts

	SVD cohorts		Control cohorts
	cohorts (n=89)	mean (SD or 95% CI)	cohorts (n=71)	mean (SD or 95% CI)
mean age*	88	69.3 (67.8, 70.9)	70	66.4 (64.6, 68.2)
% female	76	49.0 (15.9)	63	50.9 (15.0)
mean years education*	67	10.3 (9.7, 10.9)	53	10.8 (10.1, 11.6)
% hypertension	48	66.7 (23.0)	34	37.8 (20.7)
% diabetes	45	25.5 (13.7)	31	17.1 (13.5)
% hypercholesterolemia	5	55.1 (20.0)	4	35.1 (12.3)
% history of smoking	28	28.3 (16.1)	16	25.6 (16.9)

^*Mean age and mean years of education were calculated using random effects meta-analysis in the meta package in R version 3.6.1 (Schwarzer G. “meta: An R package for meta-analysis.” R News 2007, 7(3), 40–45). Only studies that presented group level data for age and years of education as mean and standard deviation were included in these meta-analyses. We did not test for differences in age, sex, level of education, or vascular risk factors between the SVD and control groups as some studies only reported these data for the SVD group, therefore, comparisons would not include all participants contributing cognitive data to the meta-analyses.