Table 2.

Comparative analysis of immunopositive macrophages density over time, intra- and between-groups.

Group	Baseline		1 month	Comparisons among time-points
CD163+ macrophages
SRP Group	3.6 ± 4.7p2p{0–11.8}	CD163 + macrophages сorrelates with CD68 + macrophages, Spearman R = 0.35, p = 0.0056	4.6 ± 5.3p2p{0–15.8}p2pCorrelates with CD68 + macrophages, Spearman R = 0.45, p = 0.0452	ns
Arg Group	3.7 ± 2.9p2p{0.8–9.1}		8.0 ± 5.8p2p{1.5–19.6}p2pDominates over CD68 + macrophages, p < 0.0001	ns
Orn Group	3.7 ± 2.5p2p{1.9–8.6}		8.8 ± 2.8p2p{6.0–13.2}p2pDominates over CD68 + macrophages, p < 0.013	Friedman test, p < 0.0001; p2p0<1 month
comparisons between groups	ns		Kruskal-Wallis test, p < 0.0001; Conv < Orn	-
CD68+ macrophages
SRP Group	1.6 ± 1.5p2p{0–3.9}	CD68 + macrophages сorrelates with CD163 + macrophages, Spearman R = 0.35, p = 0.0056	3.3 ± 3.4p2p{0–7.1}	ns
Arg Group	2.0 ± 0.9p2p{1.1–3.3}		2.2 ± 1.96p2p{0–5.0}	ns
Orn Group	1.96 ± 1.2p2p{1.0–3.7}		5.4 ± 4.2p2p{1.1–9.9}	Friedman test, p = 0.0066; p2p0<1 month
comparisons between groups	ns		Kruskal-Wallis test, p = 0.001; Arg < Orn	-

Values shown in the table are Mean ± SD and the percentile ranges of {P10 −P90} 80%, because of non-normal distribution of variables; ns – non-significant; nonparametric ANOVA, t-tests and Spearman correlation results.