Table 3.

Immunological Factors Associated with Postpartum Hepatic Flares

Factor	Postpartum flare (n=15)	No postpartum flare (n=37)	p-value
Baseline
IL-2, pg/mL	10.83±7.62	12.59±12.33	0.190
IL-4, pg/mL	2.52 (1.65–11.09)	1.33 (0.56–5.66)	0.233
IL-6, pg/mL	3.39 (1.20–52.13)	8.28 (1.19–31.43)	0.793
IL-10, pg/mL	3.33±3.75	3.60±3.50	0.983
IL-17, pg/mL	1.21 (0.08–3.00)	1.08 (0.67–2.43)	0.783
IFNγ, pg/mL	1.89 (1.31–6.98)	5.39 (2.09–16.12)	0.022
TNF-α, pg/mL	26.75 (1.62–40.18)	21.69 (4.16–35.80)	0.927
COR, μg/dL	20.19±7.67	20.97±4.65	0.028
Antepartum
IL-2, pg/mL	9.43±8.29	11.93±9.79	0.143
IL-4, pg/mL	2.36 (0.71–9.79)	1.43 (1.22–3.95)	0.635
IL-6, pg/mL	2.45 (0.55–7.99)	7.45 (1.18–44.20)	0.056
IL-10, pg/mL	3.45±3.10	4.37±4.80	0.244
IL-17, pg/mL	1.30±1.07	1.85±1.44	0.298
IFNγ, pg/mL	3.51 (2.01–6.17)	3.79 (1.89–8.08)	0.856
TNF-α, pg/mL	19.36±21.75	21.82±23.32	0.639
COR, μg/dL	25.26±6.22	26.09±4.88	0.436
Postpartum
IL-2, pg/mL	9.50 (2.07–15.75)	3.58 (1.26–13.53)	0.390
IL-4, pg/mL	3.22 (1.21–19.99)	1.61 (1.07–3.58)	0.079
IL-6, pg/mL	2.28 (0.96–45.79)	1.56 (0.52–31.17)	0.241
IL-10, pg/mL	3.18 (1.06–9.50)	2.90 (0.71–5.69)	0.298
IL-17, pg/mL	1.69±0.94	1.82±1.56	0.175
IFNγ, pg/mL	6.18 (2.96–8.95)	2.55 (1.78–6.58)	0.026
TNF-α, pg/mL	12.10 (4.58–31.50)	5.57 (2.79–21.29)	0.185
COR, μg/dL	11.48±4.46	11.34±4.03	0.595

Data are presented as mean±SD or median (IQR).

IL, interleukin; IFN, interferon; TNF, tumor necrosis factor; COR, cortisol; IQR, interquartile range.