Table 2.
Univariate and Multivariate Cox Analyses of Risk Factors for Disease Behavior Evolution in Pediatric Patients with Nonstricturing, Nonpenetrating Crohn’s Disease at Diagnosis
| Factor | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | ||
| Sex | |||||
| Male | Reference | ||||
| Female | 1.41 (0.86–2.29) | 0.163 | |||
| Family history of IBD | |||||
| No | Reference | Reference | |||
| Yes | 2.72 (1.23–5.97) | 0.013 | 2.38 (1.07–5.28) | 0.032 | |
| Age at diagnosis | |||||
| 1–9 Years | Reference | ||||
| 10–17 Years | 1.10 (0.27–4.52) | 0.887 | |||
| Isolated ileal involvement at diagnosis | |||||
| No | Reference | Reference | |||
| Yes | 8.72 (1.21–18.04) | 0.031 | 7.55 (1.04–15.57) | 0.045 | |
| Perianal fistula at diagnosis | |||||
| No | Reference | ||||
| Yes | 0.82 (0.52–1.31) | 0.422 | |||
| Growth impairment | |||||
| No | Reference | ||||
| Yes | 1.14 (0.54–2.38) | 0.720 | |||
| Positive ASCA | 2.03 (1.01–4.12) | 0.048 | 2.10 (1.03–4.25) | 0.040 | |
| Early use of medication | |||||
| Thiopurines | 0.93 (0.61–1.42) | 0.753 | |||
| Anti-TNF agents | 0.48 (0.86–3.06) | 0.046 | 0.46 (0.79–3.39) | 0.042 | |
Age at diagnosis, disease location, behavior, and growth impairment were categorized according to the Paris classification.
HR, hazard ratio; CI, confidence interval; IBD, inflammatory bowel disease; ASCA, anti-Saccharomyces cerevisiae antibodies; TNF, tumor necrosis factor.