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. 2021 Nov;195:105177. doi: 10.1016/j.antiviral.2021.105177

Fig. 2.

Fig. 2

The replication of hRV2_C3 variant is dependent on Vapendavir. (A) Quantification of infectious hRV2_C3 virus grown in presence of different capsid binders. Data are mean values of 3 independent experiments ±SD. *, p < 0.05 (t-test) (B) Thermostability test of hRV2 WT and resistant variant C3. Data are mean values of 3 independent experiments ±SD (C) Replication kinetics of WT and mutant hRV2 follow the same pattern as assessed by qRT-PCR of intracellular viral RNA levels. Data are mean values of 2 independent experiments ±SD (D) Detection of infectious virus in culture supernatants at 24 h post transfection by end-point titration in presence (isolate C3) or absence of vapendavir (WT virus). Transfection of viral RNA was performed either without (black bars) or with vapendavir (grey bars). Data are mean values of 3 independent experiments ±SD (E) Quantification of viral RNA in culture supernatants at 24 h and 48 h post transfection. ***, p < 0.0005, analyzed by t-test. Data are mean values of 3 independent experiments ±SD.