Fig. 5.

Representative structure of the G149 mutant extracted from the MD trajectory showing the interaction network from the C149 mutation to the inhibitor (pink carbons) binding site in monomer #3 of the pentamer. Intermediate residues involved are N212 and M213. Ribbon colors: Monomer #3 chain A: tan; monomer #3 chain B: pink; monomer #3 chain C: light blue; monomer #3210–214.a: green; monomer #3147–152.a cyan; all other ribbons: white. The mutation G149C in monomer #3 A-chain is at the interface of monomer #3 A-chain and monomer #4 C-chain. Image created by UCSF Chimera (Pettersen et al., 2004).