Table 1.
Vapendavir-resistant isolates carry mutations in VP1 and are cross-resistant to other capsid binders. Antiviral activity of capsid binders was assessed in a CPE-reduction assay. Data are mean values of 3 independent experiments ±SD. NA – not active.
| EC50 μM (fold change EC50) |
||||
|---|---|---|---|---|
| Virus | Genotype VP1 | Vapendavir | Pleconaril | Pirodavir |
| hRV14 | WT | 0.09 ± 0.01 | 0.20 ± 0.005 | 0.14 ± 0.1 |
| C199R | >10 (>110) | 2.9 ± 1.0 (14.5) | >27 (>192) | |
| C199Y | >10 (>110) | 3.4 ± 1.6 (17) | 8.5 ± 0.5 (60) | |
| hRV2 | WT | 0.04 ± 0.003 | 0.44 ± 0.1 | 0.46 ± 0.2 |
| G149C | >10 (>250) | >26 (>59) | >27 (>58) | |
| PV1_Sabin | WT | 2.6 ± 0.04 | NA | 33 ± 1 |
| I194F | >10 (>3.8) | NA | >54 (>1.6) | |
| EVD68_CU70 | WT | 1.4 ± 0.5 | 0.13 ± 0.06 | 2.4 ± 0.3 |
| K167E_M252L | >10 (>7) | 2.9 ± 1.6 (22) | >54 (>22) | |
| A156T_K167E | >10 (>7) | 1.4 ± 0.3 (10) | >54 (>22) | |