REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Recombinant anti-PROX1 antibody	GeneTex	Cat#GTX128354;RRID:AB_2893482
F2R rabbit pAb	ABclonal	Cat#A5641;RRID:AB_2766401
GNAI2 rabbit pAb	ABclonal	Cat#A7676;RRID:AB_2769633
Anti-alpha tubulin antibody	Abcam	Cat#ab18251;RRID:AB_2210057
GAPDH (D16H11) XP® Rabbit mAb	Cell Signaling Technology	Cat#5174;RRID:AB_10622025
p44/42 MAPK (Erk1/2) (137F5) Rabbit mAb	Cell Signaling Technology	Cat#4695;RRID:AB_390779
Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) XP® Rabbit mAb	Cell Signaling Technology	Cat#4370;RRID:AB_2315112
ß-actin	ZEN BIO	Cat#380624;RRID:AB_2893488
Goat anti-Mouse IgG (H&L) (HRP conjugate)	ZEN BIO	Cat# 511103;RRID:AB_2893489
Goat anti-rabbit IgG (H+L) secondary antibody 555	ThermoFisher Scientific	Cat#A21434;RRID:AB_2535855
Chemicals, peptides, and recombinant proteins
TritonX-100	Sigma	T9284
Bovine Serum Albumin	Sigma	A9647
4x protein loading buffer	Li-cor	928-40004
PTU	Sigma	2954-52-1
Tricaine	Sigma	886-86-2
SCH79797 dihydrochloride	MCE	HY-14994
BM Purple AP	Roche	11442074001
RNA from yeast	Roche	10109223001
Proteinase K	MERCK	39450-01-6
Recombinant human VEGF-C (Cys156Ser) protein	R&D Systems	Cat# 752-VC-025
Critical commercial assays
Tol2 kit	(Kwan et al., 2007)	N/A
LR Clonase II Plus Enzyme mix	Invitrogen	12538200
HiScribe T7 ARCA mRNA kit	NEB	#E2065S
DIG RNA Labeling Mix	Roche	11277073910
TB Green Fast RT-PCR Mix	TAKARA	RR430A
Experimental models: Cell lines
Human Primary Lymphatic Endothelial Cells	CellBiologics	H-6092
Experimental models: Organisms/strains
Zebrafish: Tg(fli1a:EGFP)y1	(Jin, 2005)	N/A
Zebrafish: Tg(fli1aep:DsRedEX)um13	(Proulx et al., 2010)	N/A
Zebrafish: Tg(fli1a:nEGFP)y7	(Roman et al., 2002)	N/A
Zebrafish: Tg(kdrl:mCherry)	(Proulx et al., 2010)	N/A
Zebrafish: Tg(lyve1b:TopazYFP)tsu	This paper	N/A
Oligonucleotides
sgRNA targeting sequence: par1 : GGGGGAAGCGGCTTTAGTTCGGG	This paper	N/A
sgRNA targeting sequence: gnai2a: GTGCAAGCAGTATCGAGCTG	This paper	N/A
sgRNA targeting sequence: mmp13b: CCTCCTGGAATCGGCATTGG	This paper	N/A
siRNA targeting sequence: PAR1: UAGAGUGUGAUGUAUGUGUAA	This paper	N/A
siRNA targeting sequence: GNA11: CAGUGAUACUUGUAUAUUACA	This paper	N/A
siRNA targeting sequence: GNA13: GGUGGUCAGAGAUCAGAAAGG	This paper	N/A
siRNA targeting sequence:GNAI2: CCUUGAGCGCCUAUGACUUTT	This paper	N/A
siRNA targeting sequence:MMP1: GCGUGUGACAGUAAGCUAACC	This paper	N/A
Morpholino: MO-par1 CCGTCACCAACAGAACCCGCAACAT	Gene Tools	N/A
Morpholino: MO-gnai2a GCTTCAGGGCGACGGATTTATGA	Gene Tools	N/A
Morpholino: MO-gna11a TCCAGAGTCATCACCACAGCGTTTG	Gene Tools	N/A
Morpholino: MO-gna11b GACTCTAAAGTCATCCCCACTGCTT	Gene Tools	N/A
Morpholino: MO-gna13a AAATCCGCCATCTTTGTAGTAGCGA	Gene Tools	N/A
Morpholino: MO-gna13b AGGAAATACGCCATCTTTGTGCAAC	Gene Tools	N/A
Morpholino: MO-F2 GCTGCAAGCCTCGGACGTGCGCCAT	Gene Tools	N/A
Probe for WISH, see Table S1	This paper	N/A
Primers for XX, see Table S1	This paper	N/A
Software and algorithms
Prism	GraphPad	7.0e