Figure 2.

Effect of i6-FP administration on oxazolone-induced colitis. (A) Chemical structure of i6-FP is shown. Oxazolone-induced colitis was induced in WT mice with or without i6-FP treatment. Survival rate (B) and percent of body weight from day 0 (C) are shown after the intrarectal administration of oxazolone in mice treated with i6-FP (n = 40) or control vehicle (n = 40). (D-F) DAI, colon length, and histologic score at sacrifice are shown. (G) Histologic hematoxylin and eosin stained sections from i6-FP-treated mice and control mice. One representative image from each group is shown (scale bars, 100 μm). Data are represented as the mean ± standard error of the mean in each group. Significance was determined using the Log-rank (Mantel-Cox) test (B) and the Welch’s t-test (C-F). ∗P < .05, ∗∗P < .01. Each symbol represents data from an individual mouse.