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. 2021 Aug 11;13(1):151–171. doi: 10.1016/j.jcmgh.2021.08.002

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Deletion of the Sele gene ameliorates hepatocellular injury in HFD^+AdCxcl1-induced NASH. WT (n = 7) and Sele KO (n = 6–7) mice were subjected to 3-month HFD feeding plus AdCxcl1 to induce NASH. Blood, sera, and liver tissues were collected and analyzed. (A) Serum ALT and AST levels. (B) Body weight (BW) and liver to body weight ratio (LW/BW). (C–E) MPO and F4/80 immunostaining of liver tissues. (F) Ionized calcium binding adaptor molecule 1 (IBA1) (all macrophages) and C-type lectin domain family 4 member F (CLEC4F) (resident Kupffer cells) immunofluorescence staining and cell ratio determination. (G) Blood leukocyte determination. ∗P < .05. DAPI, 4′,6-diamidino-2-phenylindole.