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. 2021 Aug 11;13(1):151–171. doi: 10.1016/j.jcmgh.2021.08.002

Figure 5.

Figure 5

Deletion of the Sele gene decreases apoptosis, reactive oxygen species, p38, and c-Jun-N-terminal kinase (JNK) stress kinases in HFD+AdCxcl1-induced NASH. WT (n = 7) and Sele KO (n = 6–7) were subjected to 3-month HFD feeding plus AdCxcl1 to induce NASH. Sera and liver tissues were collected and analyzed. (A) Terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick-end labeling (TUNEL) staining of liver tissues. (B) Western blot determination of poly (adenosine diphosphate-ribose) polymerase (PARP) in liver tissues. (C) RT-qPCR of liver tissues. (D) 4-hydroxynonenal (4-HNE) staining of liver tissues. (E) Western blot analyses of liver tissues and quantification of protein densities. ∗P < .05.