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. 2021 Aug 11;13(1):151–171. doi: 10.1016/j.jcmgh.2021.08.002

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Genetic deletion of the Sele gene reduces inflammation, lipolysis, and proinflammatory adipokine secretion in adipose tissue from HFD^+AdCxcl1-induced NASH. WT (n = 4–7) and Sele KO (n = 4–7) were subjected to 3-month HFD feeding plus AdCxcl1 to induce NASH. Sera and epididymal adipose tissues were collected and analyzed. (A) MPO and F4/80 immunostaining of adipose tissues. (B, C, and E) RT-qPCR of adipose tissues. (D) Determination of serum FFAs. (F) Determination of serum proinflammatory adipokines. ∗P < .05.