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. 2021 Aug 11;13(1):151–171. doi: 10.1016/j.jcmgh.2021.08.002

Figure 9.

Figure 9

S100A8/A9 is up-regulated in adipose tissue but not in the liver during NASH, which is dependent on E-selectin. (A and B) Normalized gene expression (microarray data sets obtained from Du Plessis et al9 and Lake et al25) in visceral adipose tissue (AT) and liver of patients suffering from steatosis (nAT = 7, nL = 10) and NASH (nAT = 13, nL = 16) compared with healthy controls (normal) (nL = 19, nAT = 8). (C and D) WT mice were subjected to 3-month HFD plus AdCxcl1 (HFD+AdCxcl1) to induce NASH or HFD+AdGfp (HFD) as controls. Adipose and liver tissues were collected and analyzed. Western blot analyses of S100A8/A9 dimer in adipose and liver tissues. (E–G) WT and Sele KO were subjected to 3-month HFD plus AdCxcl1 to induce NASH. Adipose and liver tissues were collected and analyzed. (E, left; and F) Immunostaining analyses of S100A8/A9 in adipose tissue and (E, right) liver tissues. (G) Western blot analyses of S100A8/A9 dimer of adipose tissues (top panel) and liver tissues (bottom panel). ∗P < .05.