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. 2021 Sep 17;13(1):95–112. doi: 10.1016/j.jcmgh.2021.09.001

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© 2021 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

CEP-1347 does not inhibit phosphorylation of JNK, ERK1, ERK2, or SMAD2 but reduces phosphorylation of p70S6K in human HSCs (LX-2). Human LX-2 cells were stimulated with (A) TGF-β or (B, C) PDGF-BB and co-stimulated with 1000 nM CEP-1347 (CEP) for (A) 24 hours or (B, C) 1 hour. (A) Densitometry data of phosphorylated protein expression levels were normalized to that of unphosphorylated proteins. The results are illustrated as representative blots (at least 6 per group; ∗P < .05; ∗∗P < .01; analysis of variance). (B) Phosphorylation of p70S6K (pp70S6K) was assessed by immunomicroscopy (green) and compared with unphosphorylated p70S6K. (C) Protein expression of pp70S6K was quantified by densitometry. Densitometric values of p70S6K were normalized to unphosphorylated p70S6K (n = 13; ∗ P < .05; analysis of variance).