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Iron-sulfur cluster synthesis. (A) Structure of IscU from Thermus thermophilus (PDB accession number 2QQ4). The gray ball is a Zn(II) ion, and the side chains of the three ligating cysteines are highlighted. (B) Structure of SufBC2D from Escherichia coli (PDB accession number 5AWF). SufC is shown in green, and SufB and SufD are shown in purple and tan, respectively. (C) Working models for ISC- and SUF-directed iron-sulfur protein maturation in Escherichia coli.
