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Polymyxin resistance levels of E. coli cells expressing wild-type MCR-1-StrepII or mutants
| MCR-1 WT/mutant | MIC (μg/ml) |
|
|---|---|---|
| Colistin | Polymyxin B | |
| None | 0.125 | 0.031 |
| MCR-1 WT | 4 | 1 |
| M105A | 0.25 | 0.0625 |
| N108S | 4 | 1 |
| L120A | 0.25 | 0.0625 |
| E246D | 2 | 0.5 |
| E246A | 0.125 | 0.031 |
| T247A | 0.25 | 0.125 |
| T285A | 0.25 | 0.0625 |
| D465E | 0.125 | 0.031 |
| D465A | 0.125 | 0.0625 |
| E468A | 0.5 | 0.125 |
| S464G | 4 | 1 |
| H478A | 0.25 | 0.0625 |
