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. 2021 Nov 15;9(11):e003616. doi: 10.1136/jitc-2021-003616

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Activity of scDb/scFv-Fc or scDb/Fab-Fc variants on proliferation and composition of T-cell subpopulations. (A) Proliferation of naive (T_N, CD45RA⁺, CCR7⁺), central memory (T_CM, CD45RA⁻, CCR7⁺), effector (T_E, CD45RA⁺, CCR7⁻) and effector memory (T_EM, CD45RA⁻, CCR7⁻) subpopulations of CD4⁺ T-cells and CD8⁺ T-cells was determined by carboxyfluorescein diacetate succinimidyl ester dilution in flow cytometry. (B) Composition of CD4⁺ and CD8⁺ T-cell subpopulation was measured in flow cytometry. Mean±SD, n=3. scDb, single-chain diabody.