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T-cell proliferation mediated by scDb/scFv-Fc and scDb/Fab-Fc variants
| Proliferation of CD4+ T-cells | Proliferation of CD8+ T-cells | |
| scDb/scFv-Fc (1-2)+1 | 599±546 | 1627±375 |
| scDb/Fab-Fc (1-2)+1 | 1075±461 | 564±335 |
| scDb/scFv-Fc (1-1)+2 | 34±8 | 144±70 |
| scDb/Fab-Fc (1-1)+2 | – | |
| scDb/scFv-Fc (2-1)+1 | 209±45 | 497±182 |
| scDb/Fab-Fc (2-1)+1 | 546±150 | 1652±363 |
EC50 (pM), mean±SD, n=3.
scDb, single-chain diabody.
