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T-cell mediated killing of tumor cells by scDb/scFv-Fc and scDb/Fab-Fc variants
| LIM1215 20,000 HER3/cell |
MCF-7 18,000 HER3/cell |
SKBR-3 14,000 HER3/cell |
FaDu 3000 HER3/cell |
|
| scDb/scFv-Fc (1-2)+1 | 41±34 | 3±1 | 3±2 | – |
| scDb/Fab-Fc (1-2)+1 | 1544±1079 | 233±89 | 43±32 | – |
| scDb/scFv-Fc (1-1)+2 | – | 688±600 | 107±80 | – |
| scDb/Fab-Fc (1-1)+2 | – | 2414±1789 | 24±22 | – |
| scDb/scFv-Fc (2-1)+1 | 65±30 | 9±6 | 4±4 | – |
| scDb/Fab-Fc (2-1)+1 | 238±165 | 61±45 | 24±29 | – |
EC50 (pM), mean±SD, n=3.
scDb, single-chain diabody.
