TABLE 1.

Biological function of potential biomarkers and related enzyme genes in ovarian cancer.

Metabolites	Log FC	CA125 + AUC	Gene	KM p-value	Poor survival	Pathway	Function
Carnosine	0.65	0.884	CNDP1	< 0.001	High	Histidine metabolism	Apoptosis
20-COOH-LTE4	−0.28	0.899	LTC4S	0.012	High	Arachidonic acid metabolism	Angiogenesis
Sebacic acid	0.2	0.879	ACADL	< 0.001	Low	Fatty acid metabolism	Inhibit metastasis
Calcitriol lactone	−0.66	0.963	DHCR24	0.011	Low	Steroid biosynthesis	Inhibit proliferation
20a,22b-Dihydroxycholesterol	0.3	0.88	CYP11A1	0.046	High	Steroid hormone biosynthesis	Proliferation
Muricholic acid	−0.28	0.944	CYP7A1	0.032	High	bile acid biosynthesis	Proliferation drug resistance
3,7,12,19-THCA	−0.47	0.935	CYP27A1	0.01	high	bile acid biosynthesis	Proliferation drug resistance
Dihydrothymine	−0.48	0.88	AGXT2	0.034	low	Pyrimidine metabolism	Anti-apoptosis drug resistance
Hexacosanoic acid	−0.14	0.926	ACSL1	0.018	low	Fatty acid metabolism	Proliferation drug