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. 2021 Oct 27;23(1):7. doi: 10.3892/etm.2021.10929

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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CLDN7 knockdown reverses the inhibitory effects of IRF2 overexpression on cell migration and invasion in OSCC cells. (A and B) Invasive ability of CAL-27 cells in the Control group, pcDNA3.1 group, pc-IRF2 group, pc-IRF2 + shNC group and pc-IRF2 + shCLDN7 group was measured using a Transwell assay. (C and D) Migration rates of CAL-27 cells in the Control group, pcDNA3.1 group, pc-IRF2 group, pc-IRF2 + shNC group and pc-IRF2 + shCLDN7 group was detected using a wound healing assay. ^***P<0.001 vs. pcDNA3.1; ^###P<0.001 vs. pc-IRF2 + shNC. CLDN7, Claudin-7; IRF2, interferon regulatory factor-2; OSCC, oral squamous cell carcinoma; sh, short hairpin RNA; NC, negative control.