Table 2.
Least square (adjusted) means and SE of outcomes at 4 months and 1 year adjusted for intake, age, education, and income.
| Outcome | Benign group | No chemotherapy group | Chemotherapy group | P-value for group differences at 4 months P-value for group differences at 1 year |
|---|---|---|---|---|
| LS mean (SE) | LS mean (SE) | LS mean (SE) | ||
| Physical QoL* | ||||
| 4 months | 67.01 (1.22) | 61.70 (1.41) | 59.05 (1.81) | <0.01 |
| 1 year | 68.29 (1.24) | 61.81 (1.41) | 67.20 (1.81)*** | <0.01 |
| Psychological QoL* | ||||
| 4 months | 106.02 (1.78) | 103.50 (2.03) | 93.94 (2.61) | <0.01 |
| 1 year | 107.35 (1.80) | 106.50 (2.03) | 104.08 (2.61)*** | 0.59 |
| Fear* | ||||
| 4 months | 26.62 (0.98) | 24.86 (1.11) | 26.45 (1.43) | 0.46 |
| 1 year | 27.98 (0.99) | 24.98 (1.11) | 26.12 (1.45) | 0.13 |
| Social QoL* | ||||
| 4 months | 76.54 (1.22) | 71.28 (1.33) | 61.62 (1.81) | <0.01 |
| 1 year | 76.87 (1.23) | 71.60 (1.33) | 69.85 (1.80)*** | <0.01 |
| Spiritual QoL* | ||||
| 4 months | 46.74 (1.05) | 48.32 (1.20) | 47.75 (1.54) | 0.61 |
| 1 year | 49.11 (1.07) | 48.21 (1.19) | 49.52 (1.54) | 0.76 |
| Depression** | ||||
| 4 months | 4.36 (0.47) | 5.03 (0.55) | 5.74 (0.55) | 0.25 |
| 1 year | 4.14 (0.48) | 4.57 (0.54) | 3.11 (0.70)*** | 0.26 |
| Anxiety*** | ||||
| 4 months | 7.47 (0.33) | 7.79 (0.38) | 8.05 (0.49) | 0.58 |
| 1 year | 7.44 (0.34) | 7.11 (0.38) | 7.71 (0.49) | 0.62 |
| Metacognitive score | ||||
| 4 months | 22.37 (0.48) | 22.57 (0.55) | 22.05 (0.70) | 0.84 |
| 1 year | 21.11 (0.48) | 22.08 (0.55) | 21.83 (0.70) | 0.40 |
| CogState identification time** | ||||
| 4 months | 2.78 (0.01) | 2.77 (0.01) | 2.78 (0.01) | 0.64 |
| 1 year | 2.77 (0.01) | 2.77 (0.01) | 2.79 (0.01) | 0.52 |
| CogState detection time** | ||||
| 4 months | 2.54 (0.01) | 2.57 (0.01) | 2.58 (0.02) | 0.17 |
| 1 year | 2.55 (0.01) | 2.56 (0.01) | 2.55 (0.02) | 0.92 |
| CogState associate learning accuracy* | ||||
| 4 months | 0.85 (0.02) | 0.87 (0.02) | 0.83 (0.03) | 0.44 |
| 1 year | 0.84 (0.02) | 0.82 (0.02) | 0.80 (0.03) | 0.44 |
| CogState spatial learning/working memory accuracy* | ||||
| 4 months | 0.45 (0.03) | 0.43 (0.03) | 0.42 (0.04) | 0.78 |
| 1 year | 0.47 (0.03) | 0.45 (0.03) | 0.44 (0.04) | 0.77 |
| CogState monitoring accuracy* | ||||
| 4 months | 1.08 (0.02) | 1.04 (0.03) | 1.08 (0.03) | 0.46 |
| 1 year | 1.09 (0.03) | 1.08 (0.03) | 1.07 (0.04) | 0.85 |
| CogState non-verbal learning/memory accuracy (one card learning)* | ||||
| 4 months | 0.82 (0.02) | 0.79 (0.02) | 0.81 (0.02) | 0.51 |
| 1 year | 0.82 (0.02) | 0.77 (0.02) | 0.80 (0.03) | 0.17 |
| CogState working memory accuracy (one card back)* | ||||
| 4 months | 1.33 (0.03) | 1.31 (0.03) | 1.25 (0.04) | 0.38 |
| 1 year | 1.32 (0.03) | 1.29 (0.04) | 1.23 (0.05) | 0.27 |
| CogState reasoning/problem solving accuracy (prediction accuracy)* | ||||
| 4 months | 0.89 (0.01) | 0.86 (0.02) | 0.86 (0.02) | 0.49 |
| 1 year | 0.89 (0.02) | 0.86 (0.02) | 0.86 (0.02) | 0.55 |
*
Higher score indicates better outcome.
**
Higher score indicates worse outcome.
***
Significant change over time within group.
Statistically significant probability (P) values for between-group differences are in bold.