Table 3.
Meta-analysis of correlations between maternal and neonatal characteristics.
| Moderator | Response variable | No. of studies | Correlation | 95% CI LB | 95% CI UB | Correlation P-value | I 2 | Q test P-value | Begg's test | Egger's test | Lin and Chu |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mat. IgG | Neo. IgG | 3 | 0.85 | 0.67 | 0.93 | <0.01 | 0% | 0.41 | 0.16 | 0.00 | 0.00 |
| Mat. IgM | Neo. IgM | 3 | 0.43 | 0.06 | 0.70 | 0.03 | 0% | 0.97 | 0.22 | 0.03 | 0.02 |
| Maternal age | Gestation | 20 | 0.15 | −0.50 | 0.08 | 0.15 | 95% | <0.01 | 0.02 | 0.00 | 0.00 |
| Weight | 20 | −33.71 | −87.24 | 19.82 | 0.22 | 80% | <0.01 | 0.30 | 0.54 | 0.27 | |
| WBC | 16 | −0.12 | −0.55 | 0.31 | 0.58 | 73% | 0.00 | 0.65 | 0.43 | 0.76 | |
| Neutrophil | 11 | 0.55 | −0.08 | 1.18 | 0.08 | 98% | <0.01 | 0.04 | 0.11 | 0.09 | |
| Lymphocytes | 13 | 0.05 | −0.11 | 0.10 | 0.96 | 69% | 0.00 | 0.67 | 0.56 | 0.90 | |
| Platelets | 9 | −2.57 | −9.66 | 4.53 | 0.48 | 79% | <0.01 | 0.75 | 0.04 | 0.24 | |
| Hemoglobin | 9 | −0.18 | −2.17 | 1.81 | 0.86 | 82% | 0.00 | 0.02 | 0.00 | 0.05 | |
| C-reactive | 17 | −1.22 | −4.20 | 1.77 | 0.42 | 99% | <0.01 | 0.58 | 0.04 | 0.00 | |
| Creatine-Kin. | 6 | −0.98 | −5.64 | 3.69 | 0.68 | 99% | <0.01 | 0.70 | 0.05 | 0.23 | |
| PCT | 8 | 0.01 | −0.08 | 0.11 | 0.26 | 96% | <0.01 | 0.70 | 0.57 | 0.12 | |
| AST | 14 | 0.51 | −5.18 | 6.21 | 0.86 | 99% | <0.01 | 0.54 | 0.77 | 0.00 | |
| ALT | 15 | 0.09 | −7.83 | 8.02 | 0.98 | 100% | <0.01 | 0.27 | 0.74 | 0.00 | |
| Bilirubin | 4 | −1.01 | −4.03 | 2.00 | 0.51 | 83% | 0.00 | 0.72 | 0.63 | 0.62 | |
| Lact Dehydro | 4 | 10.82 | 47.63 | 69.26 | 0.72 | 98% | <0.01 | 0.75 | 0.83 | 0.96 | |
| Albumin | 6 | −1.02 | −3.48 | 1.43 | 0.41 | 100% | <0.01 | 0.42 | 0.46 | 0.51 | |
| BUN | 7 | −0.03 | 0.23 | 0.17 | 0.78 | 97% | <0.01 | 1.00 | 0.43 | 0.68 | |
| D-dimer | 7 | −0.08 | −0.38 | 0.23 | 0.63 | 95% | <0.01 | 0.36 | 0.66 | 0.59 | |
| Gestational age | Weight | 21 | 111.26 | 56.04 | 166.4 | <0.01 | 56% | 0.00 | 0.18 | 0.09 | 0.14 |
| WBC | 15 | −0.26 | −0.81 | 0.30 | 0.37 | 75% | 0.00 | 0.52 | 0.51 | 0.60 | |
| Neutrophil | 10 | −1.17 | −1.84 | -0.49 | 0.00 | 95% | <0.01 | 0.05 | 0.03 | 0.14 | |
| Lymphocytes | 12 | 0.06 | −0.14 | 0.26 | 0.58 | 73% | 0.00 | 0.54 | 0.11 | 0.81 | |
| Platelets | 8 | −1.04 | −12.80 | 10.73 | 0.86 | 83% | <0.01 | 0.71 | 0.00 | 0.24 | |
| Hemoglobin | 8 | 3.25 | 0.54 | 5.97 | 0.02 | 58% | 0.04 | 0.03 | 0.09 | 0.10 | |
| C-reactive | 16 | −1.30 | −6.02 | 3.43 | 0.59 | 99% | <0.01 | 0.52 | 0.03 | 0.00 | |
| Creatine-Kin. | 6 | 7.56 | −4.63 | 19.74 | 0.22 | 99% | <0.01 | 0.70 | 0.14 | 0.23 | |
| PCT | 8 | 0.02 | −0.15 | 0.18 | 0.83 | 98% | <0.01 | 0.70 | 0.03 | 0.12 | |
| AST | 13 | −1.56 | −11.27 | 8.15 | 0.75 | 99% | <0.01 | 0.39 | 0.77 | 0.01 | |
| ALT | 14 | −0.82 | −14.29 | 12.66 | 0.91 | 100% | <0.01 | 0.18 | 0.58 | 0.00 | |
| Albumin | 5 | 0.87 | −0.33 | 2.08 | 0.16 | 92% | <0.01 | 0.80 | 0.45 | 0.67 | |
| BUN | 6 | 0.26 | 0.01 | 0.51 | 0.04 | 67% | 0.03 | 0.44 | 0.68 | 0.90 | |
| D-dimer | 6 | −0.18 | −0.61 | 0.25 | 0.41 | 95% | <0.01 | 0.72 | 0.38 | 0.66 | |
| Gestational age** | WBC | 9 | 0.48 | −0.35 | 1.31 | 0.26 | 14% | 0.35 | 0.75 | 0.05 | 0.46 |
| Neutrophil | 5 | −0.44 | −1.75 | 0.87 | 0.51 | 26% | 0.21 | 0.48 | 0.35 | 0.50 | |
| Lymphocytes | 6 | −0.03 | −0.91 | 0.85 | 0.95 | 92% | <0.01 | 1.00 | 0.07 | 0.81 | |
| Platelets | 6 | 3.71 | −19.28 | 26.70 | 0.75 | 79% | 0.01 | 1.00 | 0.19 | 0.69 | |
| Hemoglobin | 4 | 3.20 | −5.40 | 11.81 | 4.66 | 42% | 0.19 | 0.75 | 0.56 | 0.65 | |
| C-reactive | 8 | −0.33 | −1.00 | 0.35 | 0.34 | 98% | <0.01 | 105.00 | 0.79 | 0.60 | |
| Creatine-Kin. | 5 | −139.9 | −277.3 | -2.48 | 0.05 | 100% | <0.01 | 0.48 | 0.36 | 0.70 | |
| PCT | 6 | −0.16 | −1.31 | 0.99 | 0.79 | 100% | <0.01 | 0.44 | 0.06 | 0.54 | |
| AST | 9 | 3.75 | −2.21 | 9.70 | 0.22 | 0% | 0.68 | 0.75 | 0.80 | 0.91 | |
| ALT | 9 | 2.03 | −0.83 | 4.89 | 0.16 | 0% | 0.93 | 0.46 | 0.22 | 0.29 | |
| Apgar 1 min | 17 | 0.24 | −0.09 | 0.57 | 0.15 | 99% | <0.01 | 0.45 | 0.43 | 0.10 | |
| Apgar 5 min | 17 | 0.17 | −0.15 | 0.49 | 0.31 | 99% | <0.01 | 0.41 | 0.87 | 0.00 | |
| Vertical | 22 | 1.06 | 2.95 | 0.82 | 0.26 | 96% | 1.00 | 0.72 | 0.30 | 0.31 | |
| Birth weight** | WBC | 10 | 0.00 | 0.00 | 0.01 | 0.12 | 11% | 0.14 | 0.86 | 0.94 | 0.59 |
| Neutrophil | 5 | −0.01 | −0.03 | 0.01 | 0.27 | 0% | 0.03 | 0.46 | 0.45 | 0.50 | |
| Lymphocytes | 6 | 0.00 | −0.01 | 0.01 | 0.82 | 92% | <0.01 | 1.00 | 0.30 | 0.81 | |
| Platelets | 7 | 0.03 | −0.05 | 0.12 | 0.44 | 81% | 0.00 | 0.77 | 0.65 | 0.73 | |
| Hemoglobin | 5 | 0.02 | −0.01 | 0.04 | 0.30 | 23% | 0.21 | 0.23 | 0.14 | 0.20 | |
| C-reactive | 9 | 0.00 | −0.01 | 0.00 | 0.15 | 97% | <0.01 | 0.11 | 0.90 | 0.46 | |
| Creatine-Kin. | 5 | 0.15 | −0.95 | 1.26 | 0.78 | 100% | <0.01 | 0.48 | 0.04 | 0.70 | |
| PCT | 6 | −0.01 | −0.01 | −0.01 | <0.01 | 90% | <0.01 | 0.44 | 0.06 | 0.53 | |
| AST | 9 | 0.02 | 0.00 | 0.05 | 0.09 | 0% | 0.83 | 0.75 | 0.84 | 0.91 | |
| ALT | 9 | 0.01 | −0.01 | 0.03 | 0.21 | 0% | 0.90 | 0.46 | 0.31 | 0.29 | |
| Apgar 1 min | 17 | 0.00 | 0.00 | 0.00 | 0.04 | 98% | <0.01 | 0.45 | 0.10 | 0.10 | |
| Apgar 5 min | 17 | 0.00 | 0.00 | 0.00 | 0.05 | 99% | <0.01 | 0.41 | 0.58 | 0.00 | |
| Vertical | 23 | 0.00 | −0.01 | 0.00 | 0.25 | 89% | 0.00 | 0.56 | 0.87 | 0.47 |
**
Indicates that the corresponding response variable is a neonatal characteristic; unless specified, the corresponding response variable is a maternal characteristic.