Table 5.
Meta-analysis of neonatal laboratory tests and antibodies.
| Statistic | No. of studies | Reference range | Mean/prevalence (%) | 95% CI LB | 95% CI UB | I2 (%) | Q test P-value | Begg's test | Egger's test | Lin and Chu |
|---|---|---|---|---|---|---|---|---|---|---|
| WBC (109/L) | 10 | 4.5–11 | 3,040 | 2,910 | 3,170 | 41.9% | 0.08 | 0.26 | 0.43 | 0.00 |
| Normal WBC | 10 | 13.32% | 5.92% | 27.31% | 22.6% | 0.17 | 0.29 | 0.32 | 0.02 | |
| Neutrophil (109/L) | 5 | 1.5–8.0 | 14.73 | 13.05 | 16.42 | 17.2% | 0.31 | 0.86 | 0.94 | 0.60 |
| High neutrophil | 5 | 9.85% | 3.13% | 26.96% | 0.0% | 0.21 | 0.12 | 0.69 | 0.02 | |
| Neutrophil (%) | 3 | 45%−75% | 10.18 | 8.90 | 11.46 | 96.7% | <0.01 | 0.33 | 0.32 | 1.00 |
| Lymphocytes (109/L) | 6 | 1.0–5.0 | 66.67% | 47.33% | 81.66% | 94.5% | <0.01 | 0.45 | 0.85 | 0.93 |
| Low lymphocytes | 8 | 60.09 | 40.45 | 79.73 | 75.9% | <0.01 | 1.00 | 0.86 | 0.98 | |
| Lymphocytes (%) | 4 | 18%−45% | 2.87 | 1.57 | 4.16 | 89.7% | <0.01 | 0.85 | 0.15 | 0.00 |
| Platelets (103/μl) | 7 | 150–450 | 4.75% | 0.35% | 41.35% | 72.5% | <0.01 | 1.00 | 0.03 | 0.01 |
| Low platelets | 7 | 28.85 | 15.26 | 42.45 | 21.2% | 0.22 | 0.28 | 0.49 | 0.96 | |
| Hemoglobin (g/L) | 5 | 120–155 | 250.8 | 219.4 | 282.2 | 34.7% | 0.19 | 0.65 | 0.84 | 0.81 |
| Low hemoglobin | 5 | 23.37% | 11.27% | 42.26% | 0.0% | 0.73 | 0.36 | 0.31 | 0.66 | |
| CRP (mg/L) | 9 | <10 | 168.9 | 158.1 | 179.7 | 96.8% | <0.01 | 0.14 | 0.14 | 0.73 |
| Elevated CRP | 9 | 4.17% | 0.58% | 24.35% | 0.0% | 0.98 | 0.14 | 0.66 | 0.01 | |
| Creatine-kinase (U/L) | 5 | 22–198 | 1.86 | 0.56 | 3.15 | 99.6% | <0.01 | 0.11 | 0.24 | 0.37 |
| High creatine-kinase | 5 | 1.96% | 0.28% | 12.65% | 69.4% | 0.02 | 0.00 | 0.04 | 0.00 | |
| PCT (ng/ml) | 6 | <0.5 | 64.84 | 61.03 | 68.65 | 50.6% | 0.09 | 0.33 | 0.27 | 0.56 |
| High PCT | 6 | 10.65% | 1.30% | 51.92% | 23.0% | 0.21 | 0.62 | 0.92 | 0.88 | |
| AST (U/L) | 9 | <36 | 0.29 | 0.22 | 0.35 | 0.0% | 0.60 | 0.44 | 0.18 | 0.14 |
| ALT (U/L) | 9 | <36 | 23.17% | 8.40% | 49.78% | 0.0% | 0.82 | 1.00 | 0.20 | 0.02 |
| Elevated AST/ALT | 8 | 59.34 | 49.81 | 68.86 | 0.0% | 0.80 | 0.75 | 0.79 | 0.05 | |
| Albumin (g/L) | 3 | 35–50 | 14.65 | 11.93 | 17.37 | 44.7% | 0.16 | 0.46 | 0.16 | 0.00 |
| IL-6 (pg/ml) | 3 | 62.00% | 47.96% | 74.28% | 35.6% | 0.21 | 0.71 | 0.72 | 0.23 | |
| High IL-6 | 3 | 32.94 | 28.67 | 37.21 | 86.1% | <0.01 | 0.60 | 0.71 | 0.81 | |
| IgG (AU/ml) | 4 | <10 | 23.22 | 16.94 | 29.49 | 89.2% | <0.01 | 0.60 | 0.47 | 0.33 |
| High IgG | 4 | 91.10% | 32.38% | 99.97% | 2.0% | 0.30 | 0.60 | 0.27 | 0.17 | |
| IgM (AU/ml) | 4 | <10 | 72.47 | 26.41 | 118.5 | 91.6% | <0.01 | 0.04 | 0.00 | 0.99 |
| High IgM | 4 | 67.16% | 37.87% | 87.27% | 72.5% | <0.01 | 0.70 | 0.12 | 0.00 | |
| Apgar, 1 min | 20 | 7–10 | 15.86 | 0.00 | 34.65 | 96.0% | <0.01 | 0.17 | 0.16 | 0.84 |
| Apgar, 5 min | 20 | 7–10 | 20.65% | 2.75% | 70.54% | 97.6% | <0.01 | 0.70 | 0.85 | 0.83 |
| Vertical transmission | 27 | 7.94 | 7.26 | 8.62 | 88.6% | <0.01 | 0.87 | 0.75 | 0.01 |