Table 2.
Summary of the models and respective literature used to generate the database. Experiments from a total of 94 publications on SHANK3 deficiency were included in the database and categorized as described in Table 1
| Code | Strategy | Addition | Literature |
|---|---|---|---|
| ex4-22|ALL | KO | Murine | HET [92, 128, 130]; HOM [92, 128–130] |
| ex4-9|ANK | KO | Murine | HET [78, 80, 122, 124, 167, 190, 200, 207, 209, 218, 220]; HOM [78, 80, 124, 128, 140, 154–156, 167, 177, 190, 209, 218, 220, 252] |
| ex4-7|ANK | KO | Murine | HOM [90] |
| ex9|ANK | KO | Murine | HOM [82, 175] |
| ex11|SH3 | KO | Murine | HET [123, 219]; HOM [111, 118, 123, 157, 193, 202, 203, 212, 219] |
| ex13|PDZ | KO | Murine | HET [139, 176]; HOM [139, 176] |
| ex13-16|PDZ | KO | Murine | HET [106, 140, 151, 166, 181, 188, 201, 209, 213, 214]; HOM [90, 94, 140, 151, 155, 158–166, 168, 181–183, 188, 189, 192, 205, 206, 208, 209, 211, 213–215] |
| ex13-16|PDZ | cKI | Murine; Genetic restorationvia Cre-recombinase | HET [140, 196]; HOM [83, 160] |
| ex14-16|PDZ | KO | Murine | HOM [131, 133] |
| ex21|PRO | KO | Murine | HET [154, 156, 177–179, 194, 197–199]; HOM [125, 177–179, 191] |
| SHANK1 +SHANK3-ex11|SH3 | KO | Murine | HOM [138] |
| ex6|ANK | KO | Rat | HET [134, 180, 216, 217]; HOM [134, 180, 217] |
| ex11-21|SH3-PRO | KO | Rat | HET [135]; HOM [135] |
| ex6,ex12|ANK,SH3 | KO | Macaque | HET [137, 227] |
| ex21|PRO | KO | Macaque | HET or HOM [136] |
| ex8|ANK-Q321R | KI | Murine; Missense point mutation | HET [132]; HOM [132] |
| ex17|PRM-S685I | KI | Murine; Missense point mutation | HET [94]; HOM [94] |
| ex21|PRO-InsG3680 | KI | Murine; Frameshift mutation | HET [127]; HOM [127, 210] |
| ex21|PRO-R1117X | KI | Murine; Non-sense point mutation | HET [127]; HOM [127] |
| ex21|PRO-InsG3728 | KI | Murine; Frameshift mutation | HET [126, 187]; HOM [126, 187] |
| ex4-22|ALL-NEXCre | cKO | Murine; Affecting neocortical excitatory neurons | HOM [129] |
| ex4-22|ALL-Dlx5/6Cre | cKO | Murine; Affecting GABAergic forebrain neurons | HOM [129] |
| ex4-22|ALL-Drd1Cre | cKO | Murine; Affecting DRD1-positive neurons | HOM [129] |
| ex4-22|ALL-Drd2Cre | cKO | Murine; Affecting DRD2-positive neurons | HOM [129] |
| ex4-22|ALL-Nav1.8Cre | cKO | Murine; Affecting Nav1.8-positive cells | HET [92]; HOM [92] |
| ex13-16|PDZ-AdvillinCre | cKO | Murine; Affecting somatosensory neurons | HET [140]; HOM [140] |
| ex13-16|PDZ-Cdx2Cre | cKO | Murine; Affecting caudal embryonic lineage | HET [140] |
| ex14-16|PDZ-ViaatCre | cKO | Murine; Affecting GABAergic cells | HOM [131] |
| ex14-16|PDZ-Emx1Cre | cKO | Murine; Affecting excitatory neurons and glia | HOM [133] |
| SHANK3-eGFP | TG | Murine; Overexpression of SHANK3 | HEM [93, 96, 151, 205, 228–231] |
KO knockout, KI knockin, cKO conditional KO, cKI conditional KI, TG transgenic, HET heterozygous, HOM homozygous, HEM hemizygous