Table 2.
Multilevel univariable and multivariable logistic regressions predicting likelihood of disease progressiona
| Univariable OR (95% CI) | P value | Multivariable OR (95% CI) | P value | |
|---|---|---|---|---|
| Age, years | 1.00 (0.97 to 1.03) | 0.927 | – | – |
| Male sex (vs female) | 0.72 (0.42 to 1.23) | 0.225 | – | – |
| Education, years | 1.01 (0.94 to 1.09) | 0.769 | – | – |
| Genetic mutation (vs sporadic) | 1.82 (0.86 to 3.85) | 0.115 | – | – |
| bvFTD (vs PPA) | 1.30 (0.72 to 2.33) | 0.387 | – | – |
| Disease duration | 1.02 (0.91 to 1.16) | 0.711 | – | – |
| Serum NfL, pg/mL | 1.07 (1.03 to 1.11) | < 0.001 | 1.08 (1.03 to 1.13) | 0.003 |
| MMSE score | 0.93 (0.88 to 0.99) | 0.020 | 0.79 (0.64 to 0.99) | 0.040 |
| FBI score | 1.05 (1.02 to 1.08) | 0.004 | 1.13 (1.03 to 1.24) | 0.008 |
| BADL lost | 1.22 (0.77 to 1.90) | 0.391 | – | – |
| IADL lost | 1.16 (0.95 to 1.41) | 0.149 | – | – |
| Digit span | 0.84 (0.68 to 1.03) | 0.098 | – | – |
| Trail making test part A | 1.00 (1.00 to 1.01) | 0.029 | 1.00 (1.00 to 1.01) | 0.362 |
| Trail making test part B | 1.00 (1.00 to 1.00) | 0.015 | 1.00 (1.00 to 1.01) | 0.485 |
bvFTD Behavioural variant frontotemporal dementia, PPA Primary progressive aphasia, NfL Neurofilament light chain, MMSE Mini-Mental State Examination, FBI Frontal Behavioural Inventory
aTransition to a higher global CDR plus NACC FTLD score at 1-year follow-up