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. 2021 Nov 16;40:363. doi: 10.1186/s13046-021-02160-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Hsa_circ_0005273 is highly expressed in BC and exerts oncogenic effects in BC cells. A-B Hsa_circ_0005273 was highly expressed in tumor tissues compared with adjacent normal tissues. C Expression of hsa_circ_0005273 in basal-like cohort, Her2-like cohort, luminal-A and luminal-B cohort, respectively. D Relative expression of hsa_circ_0005273 in BC cell lines. E Expression of hsa_circ_0005273 was confirmed by RT-qPCR in BC cells transfected with si-NC or si-circ_0005273. F-H Effect of si-circ_0005273 on proliferation in BC cells by MTT assay. I Effect of si-circ_0005273 on proliferation in BC cels by colony formation assay. J Effect of si-circ_0005273 on proliferation in BC cells by western blotting. K Cell migration assays were performed in MDA-MB-231 using transwell chambers. L Wound healing assays were performed in MDA-MB-231 treated with sicirc_0005273. M-O Cell cycle assays were performed in BC cells treated with si-circ_0005273. P Expression of hsa_circ_0005273 was confirmed by RT-qPCR in BC cells transfected with LV-vtctor or LV-circ_0005273. Q-S Effect of LV-circ_0005273 on proliferation in BC cell lines by MTT assay. T Effect of LV-circ_0005273 on proliferation in BC cell lines by colony formation assay. *p < 0.05, **p < 0.01,*** p < 0.001,**** p < 0.0001