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. 2021 Nov 16;40:363. doi: 10.1186/s13046-021-02160-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — MiR-200a-3p is expressed at low levels and acts as a tumor suppressor in BC cells. A-B MiR-200a-3p had low expression in BC tissues compared with adjacent normal tissues. C Correlations between the expression of hsa_circ_0005273 and miR-200a-3p were found with Pearson’s correlation analysis in BC tissue samples (n = 120). D MiR-200a-3p had low expression in BC cell lines. E-G Effect of miR-200a-3p-mimics on proliferation in BC cells by MTT formation assay. H-I Effect of miR-200a-3p-inhibitor on proliferation in BC cells by colony formation assay. J Effect of miR-200a-3p-inhibitor on proliferation in BC cells by western blotting. K Wound healing assays were performed in MDA-MB-231 cell treated with miR-200a-3p-inhibitor. L Cell migration assays were performed in MDA-MB-231 cells using Transwell chambers. M-O Cell cycle assays were performed in BC cells treated with miR-200a-3p-inhibitor. *p < 0.05, **p < 0.01,*** p < 0.001,**** p < 0.0001