Table 5.
The relationship between MIR17HG and MIR155HG gene polymorphism and steroid-induced ONFH subgroup analysis
| Subgroup analysis | SNP | Model | Genotype | Control | Case | OR (95% CI) | p |
|---|---|---|---|---|---|---|---|
| Age, > 45 | rs77218221 | Codominant | C/C | 1 (0.4%) | 0 | 1 | 0.013* |
| C/T | 22 (9.5%) | 14 (20.0%) | 2.75 (1.24–6.08) | ||||
| T/T | 208 (90.0%) | 56 (80.0%) | - | ||||
| Dominant | C/C | 1 (0.4%) | 0 | 1 | 0.016* | ||
| C/T–T/T | 230 (99.6%) | 70 (100.0%) | 2.65 (1.20–5.82) | ||||
| Recessive | C/C–C/T | 23 (10.0%) | 14 (20.0%) | 1 | 0.999 | ||
| T/T | 208 (90.0%) | 56 (80.0%) | - | ||||
| Log-additive | - | - | - | 2.39 (1.12–5.08) | 0.023* | ||
| Age, > 45 | rs7318578 | Codominant | C/C | 17 (7.4%) | 10 (14.3%) | 1 | 0.042* |
| C/A | 90 (39.0%) | 23 (32.9%) | 0.82 (0.43–1.55) | ||||
| A/A | 121 (52.4%) | 37 (52.9%) | 2.62 (1.04–6.60) | ||||
| Dominant | C/C | 17 (7.4%) | 10 (14.3%) | 1 | 0.826 | ||
| C/A–A/A | 211 (91.3%) | 60 (85.7%) | 1.07 (0.60–1.91) | ||||
| Recessive | C/C–C/A | 107 (46.3%) | 33 (47.1%) | 1 | 0.022* | ||
| A/A | 121 (52.4%) | 37 (52.9%) | 2.83 (1.61–6.92) | ||||
| Log-additive | - | - | - | 1.30 (0.84–2.01) | 0.238 | ||
| Male | rs34904192 | Codominant | A/A | 24 (5.7%) | 5 (4.3%) | 1 | 0.030* |
| A/G | 171 (40.4%) | 34 (29.3%) | 0.61 (0.39–0.95) | ||||
| G/G | 228 (53.9%) | 77 (66.4%) | 0.62 (0.23–1.69) | ||||
| Dominant | A/A | 24 (5.7%) | 5 (4.3%) | 1 | 0.024* | ||
| A/G–G/G | 339 (80.1%) | 111 (95.7%) | 0.61 (0.40–0.94) | ||||
| Recessive | A/A–A/G | 195 (46.1%) | 39 (33.6%) | 1 | 0.557 | ||
| G/G | 228 (53.9%) | 77(66.4%) | 0.74 (0.27–2.00) | ||||
| Log-additive | - | - | - | 0.67 (0.47–0.98) | 0.037* | ||
| Female | rs11911469 | Codominant | C/C | 1 (1.2%) | 0 | 1 | 0.034* |
| C/A | 29 (34.9%) | 17 (20.5%) | 0.47 (0.23–0.94) | ||||
| A/A | 53 (63.9%) | 66 (79.5%) | - | ||||
| Dominant | C/C | 1 (1.2%) | 0 | 1 | 0.026* | ||
| C/A–A/A | 82 (98.8%) | 83 (100.0%) | 0.45 (0.22–0.91) | ||||
| Recessive | C/C–C/A | 30 (36.1%) | 17 (20.5%) | 1 | 0.999 | ||
| A/A | 53 (63.9%) | 66 (79.5%) | - | ||||
| Log-additive | - | - | - | 0.45 (0.23–0.88) | 0.021* | ||
| Course, months | rs77218221 | Codominant | C/C | 0 | 0 | 1 | |
| Case, > 25 | C/T | 10 (7.6%) | 13 (19.4%) | - | |||
| Control, ≤ 25 | T/T | 122 (92.4%) | 54 (80.6%) | - | |||
| Dominant | C/C | 0 | 0 | 1 | 0.037* | ||
| C/T–T/T | 132 (100.0%) | 67 (100.0%) | 2.64 (1.06–6.55) | ||||
| Recessive | C/C–C/T | 10 (7.6%) | 13 (19.4%) | 1 | - | ||
| T/T | 122 (92.4%) | 54 (80.6%) | - | ||||
| Log-additive | - | - | - | 2.64 (1.06–6.55) | 0.038* | ||
| Course, months | rs34904192 | Codominant | A/A | 4 (3.0%) | 7 (10.4%) | 1 | 0.043* |
| Case, > 25 | A/G | 43 (32.6%) | 25 (37.3%) | 1.22 (0.63–2.35) | |||
| Control, ≤ 25 | G/G | 85 (64.4%) | 35 (52.2%) | 3.84 (1.04–14.15) | |||
| Dominant | A/A | 4 (3.0%) | 7 (10.4%) | 1 | 0.240 | ||
| A/G–G/G | 128 (97.0%) | 60 (89.6%) | 1.45 (0.78–2.69) | ||||
| Recessive | A/A–A/G | 47 (35.6%) | 32 (47.8%) | 1 | 0.052 | ||
| G/G | 85 (64.4%) | 35 (52.2%) | 3.56 (0.99–12.82) | ||||
| Log-additive | - | - | - | 1.55 (0.95–2.55) | 0.082 |
* p < 0.05 indicates statistical significance