Fig. 7.

Effects of PJH on CS/LPS-induced tissue remodeling. A Sirius-red staining and immunohistochemistry of MMP-7 (X200). B Quantitative real-time PCR of MMP-7, MMP-9, and TGF-β in lung tissue. CON: control group; CS + LPS group: CS/LPS-exposed; RO group: administration of roflumilast 10 mg/kg prior to CS/LPS exposure; PJH100 group: administration of PJH 100 mg/kg prior to CS/LPS exposure; PJH200 group: administration of PJH 200 mg/kg prior to CS/LPS exposure. Results are presented as means ± SD (^#P < 0.05, ^##P < 0.01 compared with the CON group; *P < 0.05, **P < 0.01 compared with the CS + LPS group