Table 4.
Incidence of clinical symptoms in rhesus macaques, cynomolgus macaques, African green monkeys and ferrets via random-effects meta-analysis.
| Day 1 | Day 7 | Day 14 | |||||
|---|---|---|---|---|---|---|---|
| Animal model | Symptoms | I 2 | R (95% CI) | I 2 | R (95% CI) | I 2 | R (95% CI) |
| Rhesus macaque | Fever | 8.5% | 0.105 (0.030, 0.216) | 0% | 0.048 (0.004, 0.138) | 0% | 0.041 (0.000, 0.145) |
| Malaise | 84.9% | 0.209 (0.008, 0.575) | 76.4% | 0.263 (0.016, 0.661) | 0% | 0.072 (0.004, 0.209) | |
| Pneumonia | 67.2% | 0.542 (0.248, 0.821) | 49.3% | 0.779 (0.537, 0.948) | 49.3% | 0.779 (0.537, 0.948) | |
| Lymphopenia | 0% | 0.263(0.128, 0.426) | b | b | |||
| Leukocytosis | 15.1% | 0.132 (0.024, 0.308) | b | a | |||
| High ALT | 0% | 0.960 (0.773, 0.991) | 0% | 0.960 (0.773, 0.991) | 65.8% | 0.833 (0.280, 0.971) | |
| High AST | 62.9% | 0.379 (0.009, 0.888) | 5.5% | 0.766 (0.470, 0.963) | 74.3% | 0.427 (0.001, 0.972) | |
| Low albumin | a | 0% | 0.634 (0.274, 0.924) | 67.2% | 0.600 (0.045, 0.9998) | ||
| High BUN | b | b | a | ||||
| High creatinine | b | b | a | ||||
| Cynomolgus macaque | Fever | 0% | 0.052 (0.000, 0.198) | 0% | 0.052 (0.000, 0.198) | 0% | 0.048 (0.001, 0.213) |
| Malaise | 57.6% | 0.128 (0.002, 0.406) | a | a | |||
| African green monkey | Fever | 0% | 0.037 (0.006, 0.202) | a | a | ||
| Malaise | 57.6% | 0.13 (0.0, 0.41) | 35% | 0.13 (0.0, 045) | a | ||
| Ferret | Fever | 0% | 0.037 (0.001, 0.163) | 0% | 0.067 (0.012, 0.349) | 0% | 0.092 (0.017, 0.461) |
a
Not tested.
b
Incidence of zero.