. 2021 Oct;71(5):1–15. doi: 10.30802/AALAS-CM-21-000031

Table 1.

Viral vector–induced hACE2 mouse models of COVID-19

Transduction vector	Strain background	Mouse age	Infection dose	Virus strain
AdV-hACE2³⁹	BALB/c	9 wk	10⁵ FFU intranasally	USA_WA1/2020
AdV-hACE2³⁹	C57BL/6	9 wk	10⁵ FFU intranasally	USA_WA1/2020
AdV-hACE2 under CMV promoter¹¹²	BALB/c	6 to 10 wk	10⁵ PFU intranasally	CHN/IQTC01/2020
	C57BL/6
	IFNAR^−/− C57BL/6
	IFNAR^−/− C57BL/6			USA_WA1/2020
	STAT^−/− C57BL/6
	IFNγ^−/− C57BL/6
AdV-hACE2 under CMV promoter⁹⁴	BALB/c	6 wk	10⁶ PFU intranasally	USA_WA1/2020
AdV-hACE2 under CMV promoter⁹⁴	C57BL/6	6 wk	10⁶ PFU intranasally	USA_WA1/2020
AAV9-hACE2⁴⁷	C57BL/6	6 to 12 wk	10⁶ PFU intranasally	USA_WA1/2020
	IFNAR1^−/− C57BL/6
	IRF3/7^−/− C57BL/6