. 2021 Oct;71(5):1–15. doi: 10.30802/AALAS-CM-21-000031

Table 3.

Mouse-adapted SARS-CoV-2 mouse models of COVID-19

Mouse-adapted virus	Adaptation process	Challenge strain background	Mouse age	Infection dose	Original virus strain
MA²²	Reverse genetics; Q498Y/P499T S protein	BALB/c	10 wk; 1 y	10⁵ PFU intranasally	USA_WA1/2020
MA10⁵⁵	10 intranasal passages in 10-wk-old BALB/c	BALB/c	10 wk; 1 y	10⁴ PFU intranasally	USA_WA1/2020
		C57BL/6	10 wk	10⁴ PFU intranasally
		C57BL/6	10 wk	10³ PFU intranasally
		IFNR DKO	10 wk	10³ PFU intranasally
MASCp6³⁴	6 intranasal passages in 9-mo-old BALB/c	BALB/c	6 wk; 9 mo	1.6 × 10⁴ PFU intranasally	CHN/Beijing_IME-BJ05/2020