Figure 1.

Identification of significantly mutated genes (SMGs) in the aggregated melanoma cohort and their sex-biased mutation distributions. (A) Waterfall plot representation of mutational patterns of the identified SMGs. The left panel shows the gene symbols, the upper panel indicates the non-synonymous mutation counts for each patient, the middle plot illustrates the mutational patterns of the identified 15 SMGs with different mutation types colored differently, the right panel shows the mutation rate of each SMG, and the bottom panel indicates the clinical characteristics and base substitution categories. Genes highlighted in bold are the SMGs that were not previously reported. (B) Distinct mutation rates of the identified 15 SMGs between male and female patients. SMGs that were significantly differentially mutated between the two subgroups were highlighted in bold.