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. 2021 Nov 2;12:721409. doi: 10.3389/fimmu.2021.721409

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Copyright © 2021 Shi, Zhang, Yang, Yang, Zhao, Xie, Sheng, Wang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lymphocyte infiltration, immune response pathways, and genomic features associated with CFH mutations in male patients. (A) Distinct immune cell subsets and (B) lymphocyte infiltration evaluation based on CFH mutational status achieved by the ssGSEA and CIBERSORT algorithm, respectively. (C) Boxplot representation of the expression of 33 immune checkpoint genes stratified by CFH status. (D) The immune response-related pathways of CFH-mutated patients obtained from the GSEA method. The varied distributions of (E) TMB and (F) NB in CFH mutated versus wild-type subgroups. Factors highlighted in bold were identified to be statistically different in distinct sex groups. *P < 0.05; **P < 0.01; ***P < 0.001.