Table 1. Pharmacokinetic modeling using MWPharm 3.58 of three different oral doses of topiramate: 100, 2,500, and 8,000 mg.

	General population	Present case report	Patient by Brandt et al. [2]
Ingested dose (mg)	100	2,500	800
tmax (h), ranges	2.5 (2 – 3)	5.28 (3.6 – 7.8)	9.84 (8.7 – 10.9)
T1/2 (h)	± 21	16.48	23.26
Vd (L/kg)	0.55 – 0.80	0.69	0.46
Total body clearance (L/h)	1.7 – 1.8	2.39	1.04

The pharmacokinetic parameters were assessed in: 1. an adult healthy subject using published clinical PK data from the Summary of Product Characteristics of Topamax (Janssen-Cilag B.V., Breda, The Netherlands) [6]; 2. the present patient using experimental data of 5 measurements; 3. a patient with a topiramate intoxication described by Brandt et al. [2] using experimental data of 10 measurements. t_max (h) values are presented as mean and ranges. Drug dosing and calculation of the volume of distribution (L/kg) were based on lean body mass.