FIGURE 1.

Loss of CCL3 signaling improves survival of bcCML mice. A, Schematic showing initiation of CCL3^−/− bcCML model in non-irradiated mice. B, Colony forming assays. C and D, Percent live GFP⁺ cells in spleen and marrow from CCL3^−/− bcCML mice at day 10. Data represents mean ± SEM (n = 4–5). Significance tested via unpaired two-tailed t-tests. **P < .01 and ***P < .001. E, Percent survival of mice injected with CCL3^−/− leukemic cells and wild-type leukemic cells (n = 25). F, Schematic illustrating serial transplantation of CCL3^−/− bcCML in non-irradiated mice. G and H, Percent of live GFP⁺ cells in spleen and marrow from serially transplanted CCL3^−/− bcCML mice. I, Schematic showing initiation of CCL3^−/− MLL-AF9 model. J, Percent survival of MLL-AF9 murine model injected with CCL3^−/− leukemic cells and wild-type leukemic cells (n = 15). Log-rank (Mantel-Cox) test indicates significant differences with **P < .01 and ***P < .001 vs wild-type leukemic cell injections