Figure 3.

Target eculizumab concentration threshold providing complete complement inhibition (serum free C5 ≤ 0.5 μg/ml). Simulated exposure–response profile of free C5 concentration vs. eculizumab concentration, summarized using median response (gray solid line) and showing the 90% PI (gray shading). Using the threshold value 0.5 μg/ml, which is predicted to produce 20% hemolysis, the target concentration of eculizumab was identified as 116 μg/ml. C5, complement protein 5; PI, prediction interval.