Table 1.
Summary of estimated pharmacokinetic parameters.
| Parameter | Mean | SD | Median | Minimum | Maximum |
|---|---|---|---|---|---|
| CL (L/h) | 0.0106 | 0.00783 | 0.00785 | 0.00362 | 0.0448 |
| V1 (L) | 2.54 | 0.758 | 2.44 | 1.32 | 5.25 |
| V2 (L) | 2.73 | 0.554 | 2.61 | 1.76 | 4.26 |
| Q (L/h) | 0.251 | 0.107 | 0.218 | 0.0956 | 0.605 |
| Observed Cmax (μg/ml) | 939 | 353 | 912 | 265 | 1,640 |
| Cmax, ss (μg/ml) | 845 | 295 | 878 | 253 | 1,580 |
| Ctrough, ss (μg/ml) | 348 | 180 | 348 | 29.6 | 831 |
| Terminal half-life (h) | 436 | 152 | 453 | 136 | 952 |
| AUCss (μg·h/ml) | 154,000 | 68,600 | 153,000 | 26,800 | 331,000 |
Data are summaries of the individual Bayesian estimates. AUCss, area under the concentration–time curve at steady state; CL, clearance; Cmax, peak concentration; Ctrough, trough concentration; Q, intercompartmental clearance; SD, standard deviation; ss, steady state; V1, volume of distribution in the central compartment; V2, volume of distribution in the peripheral compartment.