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. 2021 May 25;49(12):2131–2136. doi: 10.1097/CCM.0000000000005097

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Copyright © 2021 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 1. — Corticosteroid response in coronavirus disease 2019 (COVID-19). Distribution of glucocorticoid receptor alpha (GCR-α) (A) and glucocorticoid-inducible leucine zipper (GILZ) (B) expression in 26 COVID-19 critically ill patients and 33 non-COVID-19 critically ill patients on ICU admission. Data are presented as scatter plots. Line in the middle: median value; lower and upper lines: 25th–75th percentiles. **p < 0.01, ****p < 0.0001 by Mann-Whitney U test. C, Morning cortisol levels were measured in 26 COVID-19 critically ill patients and in 33 non-COVID-19 critically ill patients on ICU admission. Data are presented as box plots. Line in the box: median value; box edges: 25th to 75th percentiles; whiskers: range of values; horizontal line: cortisol levels 10 µg/dL. **p < 0.01 by Mann-Whitney U test. Distribution of interleukin-6 (D) and interleukin-10 (E) in 26 COVID-19 critically ill patients and 33 non-COVID-19 critically ill patients on ICU admission. Data are presented as scatter plots. Line in the middle: median value; lower and upper lines: 25th–75th percentiles. mRNA = messenger RNA.