TABLE 1.
Summary of the Pooled Estimates of Prevalence of Organ Dysfunctions Among Adult Patients Hospitalized in the ICU
| Dysfunction | No. of Studies | No. of Patients | No. With Dysfunction | Prevalence (%) | 95% CI | I2 (%) |
|---|---|---|---|---|---|---|
| Acute respiratory distress syndrome | 41 | 21,678 | 15,809 | 87.5 | 83.3–90.7 | 98 |
| Mild (200 < Pao2:Fio2 < 300) | 21 | 9,688 | 1,796 | 21.5 | 13.9–31.8 | 98 |
| Moderate (100 < Pao2:Fio2 < 200) | 26 | 33,210 | 16,505 | 43.7 | 32.4–55.8 | 100 |
| Severe (Pao2:Fio2 < 100) | 28 | 20,034 | 7,377 | 32.1 | 26.3–39.8 | 99 |
| Septic shock | 22 | 3,262 | 1,189 | 36.4 | 27.2–46.8 | 96 |
| Lactate elevated (> 2 mmol/L) | 9 | 978 | 390 | 47.2 | 33.5–61.3 | 93 |
| Renal dysfunction | 32 | 32,785 | 11,215 | 28.6 | 23.1–33.6 | 98 |
| Coagulopathy | 25 | 3,346 | 724 | 17.7 | 13.1–23.3 | 92 |
| Liver dysfunction | 19 | 2,045 | 495 | 20.3 | 12.3–31.6 | 95 |
| CNS dysfunction | 6 | 4,151 | 755 | 8.8 | 4.0–18.1 | 95 |
Prevalence (%) is considered the pooled estimate of each organ dysfunction as calculated in the respective meta-analysis of the respective studies providing such data, taking into consideration different weights of each study in the meta-analysis (resulting from number of patients in each meta-analyzed trial).