TABLE 1.
Distribution of Clinical Manifestations Related to Syphilis by Anatomical Site of Oral Cavity
| No. Cases | Lesions by Clinical Manifestation, n (%)* | No. Cases With Single Location Involved | Lesions by Clinical Manifestation, n (%)* | |||||
|---|---|---|---|---|---|---|---|---|
| Ulcer | Mucous Patch | Nodule | Ulcer | Mucous Patch | Nodule | |||
| Anatomic location | ||||||||
| Tongue | 62 (42.8) | 31 (50.0) | 27 (43.5) | 4 (6.5) | 33 (37.5) | 21 (63.6) | 9 (27.3) | 3 (9.1) |
| Lip | ||||||||
| Upper lip | 24 (16.6) | 16 (66.7) | 8 (33.3) | 0 | 13 (14.8) | 11 (84.6) | 2 (15.4) | 0 |
| Lower lip | 37 (25.5) | 15 (40.5) | 20 (54.1) | 2 (5.4) | 16 (18.2) | 8 (50.0) | 6 (37.5) | 2 (12.5) |
| Nonspecific | 7 (4.8) | 3 (42.8) | 4 (57.1) | 0 | 1 (1.1) | 0 | 1 (100.0) | 0 |
| Lip—total† | 58 (40.0) | — | — | — | 26 (29.5) | 18 (69.2) | 6 (23.1) | 2 (7.7) |
| Palate | ||||||||
| Hard palate | 19 (13.1) | 8 (42.1) | 10 (52.6) | 1 (5.3) | 6 (6.8) | 4 (66.7) | 1 (16.7) | 1 (16.7) |
| Soft palate | 22 (15.2) | 10 (45.5) | 10 (45.5) | 2 (9.1) | 8 (9.1) | 5 (62.5) | 2 (25.0) | 1 (12.5) |
| Nonspecific | 16 (11.0) | 8 (50.0) | 8 (50.0) | 0 | 6 (6.8) | 4 (66.7) | 2 (33.3) | 0 |
| Palate-total† | 49 (33.8) | — | — | — | 17 (19.3) | 11 (64.7) | 5 (29.4) | 1 (5.9) |
| Buccal mucosa | 29 (20.0) | 13 (44.8) | 15 (51.7) | 1 (3.4) | 6 (6.8) | 4 (66.7) | 2 (33.3) | 0 |
| Commissure | 13 (9.0) | 8 (61.5) | 5 (38.5) | 0 | 4 (4.5) | 3 (75.0) | 1 (25.0) | 0 |
| Tonsil | 6 (4.1) | 2 (33.3) | 4 (80.0) | 0 | 0 | 0 | 0 | 0 |
| Uvula | 5 (3.4) | 1 (20.0) | 4 (80.0) | 0 | 0 | 0 | 0 | 0 |
| Vestibular | 4 (2.8) | 2 (50.0) | 2 (50.0) | 0 | 1 (1.1) | 1 (100.0) | 0 | 0 |
| Lingual frenulum | 3 (2.1) | 2 (66.7) | 1 (33.3) | 0 | 0 | 0 | 0 | 0 |
| Gingiva/gum | 3 (2.1) | 1 (33.3) | 2 (66.7) | 0 | 1 (1.1) | 0 | 1 (100.0% | 0 |
| Floor of mouth | 2 (1.4) | 1 (50.0) | 0 | 1 (50.0) | 0 | 0 | 0 | 0 |
| χ2 = 4.58, P = 0.97 | ||||||||
| Stage of syphilis | ||||||||
| Primary | 29 (20.0) | — | — | — | 24 (27.3) | 22 (91.7) | 2 (8.3) | 0 |
| Secondary | 91 (62.8) | — | — | — | 46 (52.3) | 23 (50.0) | 18 (39.1) | 5 (10.9) |
| Early (no staging) | 20 (13.8) | — | — | — | 13 (14.8) | 9 (69.2) | 4 (30.8) | 0 |
| Primary and secondary | 5 (3.4) | — | — | — | 5 (5.7) | 4 (80.0) | 0 | 1 (20.0) |
| χ2 = 16.21, P = 0.013 | ||||||||
| Total† | 145 | — | — | — | 88 | 58 (65.9) | 24 (27.3) | 6 (6.8) |
*Ulcer includes chancre, and ulcerative or erosive lesion; mucous plaque includes mucous patch, reddish patch or whitish patch, and plaque; nodule includes nodular, popular or papillomatous lesion.
†The sum of cases with lesions in anatomical sites may larger than the total number of the included cases (n = 145) because some cases may have more than 1 location with the lesion.