Biodegradable PLCL pressure-sensitive adhesives were sprayed onto plastic bandages, producing comparable adhesive strength to a conventional polybutylene pressure-sensitive adhesive. Optical microscopy of (A) an uncoated plastic bandage, (B) a plastic bandage coated with a conventional pressure-sensitive adhesive (PSA), and (C) a plastic bandage coated with a PLCL blend adhesive. (D) Differential scanning calorimetry of HMW PLCL, PLCL blend adhesive, and conventional PSA utilized with band-aid. (E) Pull-apart adhesion strength between bandage and porcine skin for neat and blended PLCL, conventional bandage PSA, Progel lung sealant (HSA-PEG), and SwiftSet topical skin adhesive (CA). (F) Wound closure strength of PLCL 50:50 L/H blend compared to those of pure LMW and HMW polymers. Asterisks indicate statistical significance: * P < 0.05, ** P < 0.01.