Table.3.

Association between histological response and ≥ 30% relative decline in MRI-PDFF

	Relative decline in MRI-PDFF		≥ 30% vs < 30% relative decline in MRI-PDFF
Histologic response (≥ 1 point/stage decrease)	≥ 30% (n = 25)	< 30% (n = 75)	Odds ratio	95%CI	p value
Steatosis	64%	32%	3.78	1.5-9.8	0.006
Lobular inflammation	44%	24%	2.49	0.9-6.4	0.06
Ballooning	56%	41%	1.81	0.7-4.5	0.2
NAS response*	60%	24%	4.75	1.8-12	0.001
Fibrosis**	50%	21%	3.75	1.2-12	0.03

^*NAS response is defined as ≥ 2 points improvement in NAS with no worsening of fibrosis.

^**Fibrosis response limits to patients with fibrosis stage 1-4 at baseline.

MRI, magnetic resonance imaging; PDFF, proton density fat fraction; NAS, nonalcoholic fatty liver disease activity score; CI, confidence interval