FIG 2.

Infection of B. pertussis induces cough in Sprague-Dawley rats. Coughs were measured each day of the 12-day infection using whole-body plethysmography. Coughs were counted for mock challenge rats (A), rats infected with D420 (B), and rats infected with Tohama 1 (C). (D) Summary of results (see panels A to C) shown as means ± the standard errors of the mean (SEM; n = 4 to 8). (E) AUC, represented as averages of coughs per 15 min for each rat. P values were determined by two-way ANOVA, followed by a Bonferroni comparison test and an unpaired Student t test for AUC (*, P < 0.05 [D420 compared to the mock-challenged control group], #, P < 0.05 [Tohama 1 compared to the mock challenged control group]).