TABLE 11.
Results of meta-analyses estimating summary proportions of clearance in first procedures, all adverse events, and specific adverse events
| Intraductal therapy |
Conventional therapy |
|||
|---|---|---|---|---|
| No. of contributing studies |
Summary estimates of proportion (95% confidence interval) |
No. of contributing studies |
Summary estimates of proportion (95% confidence interval) |
|
| Clearance in first procedure, all studies | 28 | .69 (.62-.75) | 66 | .81 (.77-.84) |
| Studies without papillary dilation | 24 | .68 (.60-.75) | 13 | .56 (.42-.69) |
| Studies with papillary dilation | 4 | .75 (.66-.83) | 53 | .85 (.82-.88) |
| Any adverse events | 49 | .08 (.06-.11) | 118 | .09 (.08-.11) |
| Studies without papillary dilation | 46 | .08 (.05-.10) | 35 | .11 (.07-.15) |
| Studies with papillary dilation | 3 | .11 (.01-.25) | 83 | .09 (.07-.10) |
| Pancreatitis | 49 | .00 (.00-.00) | 116 | .03 (.02-.04) |
| Studies without papillary dilation | 46 | .00 (. 00-.00) | 33 | .02 (.01-.04) |
| Studies with papillary dilation | 3 | .04 (.01-.09) | 83 | .03 (.02-.04) |
| Cholangitis | 49 | .01 (.00-.02) | 116 | .01 (.00-.01) |
| Studies without papillary dilation | 46 | .01 (.00-.02) | 33 | .03 (.01-.05) |
| Studies with papillary dilation | 3 | .02 (.00-.06) | 83 | .00 (.00-.00) |
| Bleeding | 49 | .01 (.00-.02) | 116 | .02 (.01-.03) |
| Studies without papillary dilation | 46 | .00 (.00-.01) | 33 | .02 (.01-.03) |
| Studies with papillary dilation | 3 | .03 (.00-.18) | 83 | .02 (.01-.03) |
| Sedation adverse event | 49 | .00 (.00-.00) | 116 | .00 (.00-.00) |
| Studies without papillary dilation | 46 | .00 (.00-.00) | 33 | .00 (.00-.00) |
| Studies with papillary dilation | 3 | .00 (.00-.01) | 83 | .00 (.00-.00) |
| Otder adverse event | 49 | .01 (.00-.02) | 116 | .00 (.00-.00) |
| Studies without papillary dilation | 46 | .01 (.00-.02) | 33 | .00 (.00-.01) |
| Studies with papillary dilation | 3 | .00 (.00-.01) | 83 | .00 (.00-.00) |
| Requirement for mechanical lithotripsy | 18 | .19 (.10-.29) | 93 | .29 (.23-.36) |
| Studies without papillary dilation | 15 | .17 (.08-.27) | 22 | .74 (.53-.91) |
| Studies with papillary dilation | 3 | .28 (.05-.58) | 72 | .18 (.15-.22) |
| Clearance with laser | 26 | .94 (.91-.96) | N/A | N/A |
| Studies with papillary dilation | 2 | .93 (.87-.98) | ||
| Studies without papillary dilation | 24 | .94 (.91-.97) | ||
| Clearance with electrohydraulic lithotripsy | 17 | .90 (.85-.95) | N/A | N/A |
| Studies with papillary dilation | 1 | .90 (.60-.98) | ||
| Studies without papillary dilation | 16 | .90 (.84-.85) | ||
N/A, Not applicable.