Table 2.
Differentially methylated regions (DMRs) in T2DM on metformin versus newly diagnosed cases.
| Hypermethylated DMRs | |||||
|---|---|---|---|---|---|
| Gene Name | Genomic Coordinates | DMR Length | log2FC | p-Value | q-Value |
| XAGE1E | chrX:52260741-52261020 | 279 | 1.66 | <0.001 | 0.001 |
| XAGE1B | chrX:52260741-52261020 | 279 | 1.66 | <0.001 | 0.001 |
| KIAA1467 | chr12:13198981-13199200 | 219 | 1.62 | <0.001 | 0.001 |
| ASB2 | chr14:94442921-94443160 | 239 | 1.6 | <0.001 | 0.001 |
| GABPA | chr21:27105221-27105420 | 199 | 1.56 | <0.001 | 0.004 |
| ZNF346 | chr5:176448161-176448360 | 199 | 1.47 | <0.001 | 0.004 |
| FKBP8 | chr19:18655321-18655520 | 199 | 1.4 | <0.001 | 0.001 |
| CTAGE15 | chr7:143268761-143269080 | 319 | 1.38 | <0.001 | 0.001 |
| VIPR1 | chr3:42531141-42531360 | 219 | 1.37 | <0.001 | 0.026 |
| TMEM204 | chr16:1584901-1585100 | 199 | 1.31 | <0.001 | 0.002 |
| RNF103-CHMP3 | chr2:86948981-86949200 | 219 | 1.31 | <0.001 | 0.010 |
| PARVB | chr22:44394581-44394780 | 199 | 1.26 | <0.001 | 0.004 |
| POTED | chr21:14980641-14980880 | 239 | 1.23 | <0.001 | 0.001 |
| STAG2 | chrX:123095761-123095980 | 219 | 1.21 | <0.001 | 0.008 |
| KCNQ3 | chr8:133459461-133459680 | 219 | 1.19 | <0.001 | 0.026 |
| TBCE | chr1:235532261-235532520 | 259 | 1.16 | <0.001 | 0.001 |
| GAREML | chr2:26393901-26394160 | 259 | 1.14 | <0.001 | 0.003 |
| SEPT12 | chr16:4838741-4839000 | 259 | 1.13 | <0.001 | 0.003 |
| OR6C3 | chr12:55727101-55727440 | 339 | 1.11 | <0.001 | 0.011 |
| PPP1R32 | chr11:61247661-61247920 | 259 | 1.1 | <0.001 | 0.003 |
| ZNF169 | chr9:97023241-97023440 | 199 | 1.07 | <0.001 | 0.024 |
| TAS1R1 | chr1:6616841-6617200 | 359 | 1.07 | <0.001 | 0.001 |
| Hypomethylated DMRs | |||||
| TPD52L2 | chr20:62497561-62497920 | 359 | −1 | <0.001 | 0.003 |
| GAGE7 | chrX:49217161-49217580 | 419 | −1.15 | <0.001 | 0.011 |
| NUDT10 | chrX:51075781-51076040 | 259 | −1.37 | <0.001 | 0.001 |
| OPN1MW2 | chrX:153446941-153447140 | 199 | −1.39 | <0.001 | 0.008 |
| OPN1MW | chrX:153446941-153447140 | 199 | −1.39 | <0.001 | 0.008 |
| BRDT | chr1:92415321-92415520 | 199 | −1.39 | <0.001 | 0.023 |
| ELAC2 | chr17:12919641-12919840 | 199 | −1.45 | <0.001 | 0.012 |
| SLC25A35 | chr17:8196461-8196680 | 219 | −1.52 | <0.001 | 0.004 |
| C18orf8 | chr18:21081741-21081940 | 199 | −1.55 | <0.001 | 0.002 |
| SLC28A1 | chr15:85429461-85429660 | 199 | −1.67 | <0.001 | 0.008 |
| FBXW8 | chr12:117350081-117350320 | 239 | −1.79 | <0.001 | 0.008 |
Gene name refers to the name of the DMR-associated gene. Genomic coordinates refers to the genomic locus of the DMR. DMR Length refers to the length of the DMR. log2FC refers to the fold change of normalized tag counts between two groups (log2 transformed). The p-value refers to the p-value of the DMR, the smaller, the more significant. The q-value refers to the Benjamini-Hochberg False Discovery Rate (BH FDR) corrected p-value.