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. Author manuscript; available in PMC: 2022 Jan 9.
Published in final edited form as: J Neurosurg Pediatr. 2021 Jul 9;28(4):458–468. doi: 10.3171/2021.2.PEDS201006

FIG. 6.

FIG. 6.

To provide a standard tool for researchers and clinicians, normal curves resembling head circumference growth curves were fit using GAMLSS to show the 3rd, 15th, 50th, 85th, and 97th percentiles of normal brain volume growth for females (A) and males (B), as well as the brain/CSF ratio for females (C) and males (D). The growth curves were modeled using a Box-Cox power exponential distribution and smoothed using fractional polynomials. Both male and female brain volume plots include insets for brain growth from birth to age 2 years, as well as CSF accumulation from birth to age 18 years, in order to provide a comprehensive picture of brain growth dynamics in the pediatric age range.